ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity

Ataxia-telegiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), and p85α are key tumour suppressors. Whether ATM regulates PTEN expression and influence platinum sensitivity is unknown. We generated ATM knockdowns (KD) and CRISPR knock outs (KO) in glioblastoma (LN18, LN229) and ovarian c...

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Publicado no:Cells
Main Authors: Ali, Reem, Alabdullah, Muslim, Miligy, Islam, Normatova, Makhliyo, Babaei-Jadidi, Roya, S. Nateri, Abdolrahman, Rakha, Emad A., Madhusudan, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848936/
https://ncbi.nlm.nih.gov/pubmed/31635307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101271
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