ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity

Ataxia-telegiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), and p85α are key tumour suppressors. Whether ATM regulates PTEN expression and influence platinum sensitivity is unknown. We generated ATM knockdowns (KD) and CRISPR knock outs (KO) in glioblastoma (LN18, LN229) and ovarian c...

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Detaylı Bibliyografya
Yayımlandı:Cells
Asıl Yazarlar: Ali, Reem, Alabdullah, Muslim, Miligy, Islam, Normatova, Makhliyo, Babaei-Jadidi, Roya, S. Nateri, Abdolrahman, Rakha, Emad A., Madhusudan, Srinivasan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848936/
https://ncbi.nlm.nih.gov/pubmed/31635307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101271
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