FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers

SIMPLE SUMMARY: Overall survival outcomes, despite platinum-based chemotherapy, for patients with advanced ovarian cancer remains poor. Increased DNA repair capacity is a key route to platinum resistance in ovarian cancer. In the current study, we show that FEN1, a key player in DNA repair, is overe...

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Bibliografske podrobnosti
izdano v:Cancers (Basel)
Main Authors: Mesquita, Katia A., Ali, Reem, Doherty, Rachel, Toss, Michael S., Miligy, Islam, Alblihy, Adel, Dorjsuren, Dorjbal, Simeonov, Anton, Jadhav, Ajit, Wilson, David M., Hickson, Ian, Tatum, Natalie J., Rakha, Emad A., Madhusudan, Srinivasan
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070745/
https://ncbi.nlm.nih.gov/pubmed/33919707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081866
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