Structural basis of malaria RIFIN binding by LILRB1-containing antibodies

We previously reported that certain Plasmodium falciparum RIFINs, variant surface antigens expressed on infected erythrocytes(1), bind to the inhibitory receptor LAIR1 and insertions of DNA encoding LAIR1 into immunoglobulin genes generate RIFIN-specific antibodies(2,3). To address the general relev...

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Publicado no:Nature
Main Authors: Chen, Yiwei, Xu, Kai, Piccoli, Luca, Foglierini, Mathilde, Tan, Joshua, Jin, Wenjie, Gorman, Jason, Tsybovsky, Yaroslav, Zhang, Baoshan, Traore, Boubacar, Silacci-Fregni, Chiara, Daubenberger, Claudia, Crompton, Peter D., Geiger, Roger, Sallusto, Federica, Kwong, Peter D., Lanzavecchia, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068667/
https://ncbi.nlm.nih.gov/pubmed/33790470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03378-6
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