Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

RIFIN, a large family of Plasmodium variant surface antigens, plays a crucial role in malaria pathogenesis by mediating immune suppression through activation of inhibitory receptors such as LAIR1, and antibodies with LAIR1 inserts have been identified that bind infected erythrocytes through RIFIN. H...

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Vydáno v:Nat Commun
Hlavní autoři: Xu, Kai, Wang, Yiran, Shen, Chen-Hsiang, Chen, Yiwei, Zhang, Baoshan, Liu, Kevin, Tsybovsky, Yaroslav, Wang, Shuishu, Farney, S. Katie, Gorman, Jason, Stephens, Tyler, Verardi, Raffaello, Yang, Yongping, Zhou, Tongqing, Chuang, Gwo-Yu, Lanzavecchia, Antonio, Piccoli, Luca, Kwong, Peter D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270905/
https://ncbi.nlm.nih.gov/pubmed/34244481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24291-6
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