Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains

The SARS-CoV-2 spike employs mobile receptor-binding domains (RBDs) to engage the ACE2 receptor and to facilitate virus entry. Antibodies can engage RBD but some, such as CR3022, fail to inhibit entry despite nanomolar spike affinity. Here we show the SARS-CoV-2 spike to have low unfolding enthalpy...

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Publicado no:bioRxiv
Main Authors: Zhou, Tongqing, Tsybovsky, Yaroslav, Olia, Adam S., Gorman, Jason, Rapp, Micah A., Cerutti, Gabriele, Chuang, Gwo-Yu, Katsamba, Phinikoula S., Nazzari, Alexandra, Sampson, Jared M., Schon, Arne, Wang, Pengfei D., Bimela, Jude, Shi, Wei, Teng, I-Ting, Zhang, Baoshan, Boyington, Jeffrey C., Sastry, Mallika, Stephens, Tyler, Stuckey, Jonathan, Wang, Shuishu, Friesner, Richard A., Ho, David D., Mascola, John R., Shapiro, Lawrence, Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337388/
https://ncbi.nlm.nih.gov/pubmed/32637958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.04.187989
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