Structural basis of malaria RIFIN binding by LILRB1-containing antibodies

We previously reported that certain Plasmodium falciparum RIFINs, variant surface antigens expressed on infected erythrocytes(1), bind to the inhibitory receptor LAIR1 and insertions of DNA encoding LAIR1 into immunoglobulin genes generate RIFIN-specific antibodies(2,3). To address the general relev...

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Vydáno v:Nature
Hlavní autoři: Chen, Yiwei, Xu, Kai, Piccoli, Luca, Foglierini, Mathilde, Tan, Joshua, Jin, Wenjie, Gorman, Jason, Tsybovsky, Yaroslav, Zhang, Baoshan, Traore, Boubacar, Silacci-Fregni, Chiara, Daubenberger, Claudia, Crompton, Peter D., Geiger, Roger, Sallusto, Federica, Kwong, Peter D., Lanzavecchia, Antonio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068667/
https://ncbi.nlm.nih.gov/pubmed/33790470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03378-6
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