Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome

Chloramphenicol (CHL) is a ribosome-targeting antibiotic that binds to the peptidyl transferase center (PTC) of the bacterial ribosome and inhibits peptide bond formation. As an approach for modifying and potentially improving the properties of this inhibitor, we explored ribosome binding and inhibi...

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書誌詳細
出版年:Antibiotics (Basel)
主要な著者: Chen, Chih-Wei, Pavlova, Julia A., Lukianov, Dmitrii A., Tereshchenkov, Andrey G., Makarov, Gennady I., Khairullina, Zimfira Z., Tashlitsky, Vadim N., Paleskava, Alena, Konevega, Andrey L., Bogdanov, Alexey A., Osterman, Ilya A., Sumbatyan, Natalia V., Polikanov, Yury S.
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8066774/
https://ncbi.nlm.nih.gov/pubmed/33916420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antibiotics10040390
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