Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome

Chloramphenicol (CHL) is a ribosome-targeting antibiotic that binds to the peptidyl transferase center (PTC) of the bacterial ribosome and inhibits peptide bond formation. As an approach for modifying and potentially improving the properties of this inhibitor, we explored ribosome binding and inhibi...

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Gepubliceerd in:Antibiotics (Basel)
Hoofdauteurs: Chen, Chih-Wei, Pavlova, Julia A., Lukianov, Dmitrii A., Tereshchenkov, Andrey G., Makarov, Gennady I., Khairullina, Zimfira Z., Tashlitsky, Vadim N., Paleskava, Alena, Konevega, Andrey L., Bogdanov, Alexey A., Osterman, Ilya A., Sumbatyan, Natalia V., Polikanov, Yury S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8066774/
https://ncbi.nlm.nih.gov/pubmed/33916420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antibiotics10040390
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