Binding and action of amino-acid analogues of chloramphenicol upon the bacterial ribosome

Antibiotic chloramphenicol (CLM) binds with a moderate affinity at the peptidyl transferase center of the bacterial ribosome and inhibits peptide bond formation. As an approach for modifying and potentially improving properties of this inhibitor, we explored ribosome binding and inhibitory activity...

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Detaylı Bibliyografya
Yayımlandı:J Mol Biol
Asıl Yazarlar: Tereshchenkov, Andrey G., Dobosz-Bartoszek, Malgorzata, Osterman, Ilya A., Marks, James, Sergeeva, Vasilina A., Kasatsky, Pavel, Komarova (Andreyanova), Ekaterina S., Stavrianidi, Andrey A., Rodin, Igor A., Konevega, Andrey L., Sergiev, Petr V., Sumbatyan, Natalia V., Mankin, Alexander S., Bogdanov, Alexey A., Polikanov, Yury S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023675/
https://ncbi.nlm.nih.gov/pubmed/29410130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.01.016
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