Binding and action of amino-acid analogues of chloramphenicol upon the bacterial ribosome

Antibiotic chloramphenicol (CLM) binds with a moderate affinity at the peptidyl transferase center of the bacterial ribosome and inhibits peptide bond formation. As an approach for modifying and potentially improving properties of this inhibitor, we explored ribosome binding and inhibitory activity...

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Bibliographic Details
Published in:J Mol Biol
Main Authors: Tereshchenkov, Andrey G., Dobosz-Bartoszek, Malgorzata, Osterman, Ilya A., Marks, James, Sergeeva, Vasilina A., Kasatsky, Pavel, Komarova (Andreyanova), Ekaterina S., Stavrianidi, Andrey A., Rodin, Igor A., Konevega, Andrey L., Sergiev, Petr V., Sumbatyan, Natalia V., Mankin, Alexander S., Bogdanov, Alexey A., Polikanov, Yury S.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023675/
https://ncbi.nlm.nih.gov/pubmed/29410130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.01.016
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