Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides

Although macrolides are known as excellent antibacterials, their medical use has been significantly limited due to the spread of bacterial drug resistance. Therefore, it is necessary to develop new potent macrolides to combat the emergence of drug-resistant pathogens. One of the key steps in rationa...

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Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Khabibullina, Nelli F., Tereshchenkov, Andrey G., Komarova, Ekaterina S., Syroegin, Egor A., Shiriaev, Dmitrii I., Paleskava, Alena, Kartsev, Victor G., Bogdanov, Alexey A., Konevega, Andrey L., Dontsova, Olga A., Sergiev, Petr V., Osterman, Ilya A., Polikanov, Yury S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2019
Onderwerpen:
Chemistry; Biosynthesis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535518/
https://ncbi.nlm.nih.gov/pubmed/30936109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02266-18
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