Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides

Although macrolides are known as excellent antibacterials, their medical use has been significantly limited due to the spread of bacterial drug resistance. Therefore, it is necessary to develop new potent macrolides to combat the emergence of drug-resistant pathogens. One of the key steps in rationa...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Khabibullina, Nelli F., Tereshchenkov, Andrey G., Komarova, Ekaterina S., Syroegin, Egor A., Shiriaev, Dmitrii I., Paleskava, Alena, Kartsev, Victor G., Bogdanov, Alexey A., Konevega, Andrey L., Dontsova, Olga A., Sergiev, Petr V., Osterman, Ilya A., Polikanov, Yury S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Chemistry; Biosynthesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535518/
https://ncbi.nlm.nih.gov/pubmed/30936109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02266-18
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