Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides

Although macrolides are known as excellent antibacterials, their medical use has been significantly limited due to the spread of bacterial drug resistance. Therefore, it is necessary to develop new potent macrolides to combat the emergence of drug-resistant pathogens. One of the key steps in rationa...

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Gardado en:
Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Khabibullina, Nelli F., Tereshchenkov, Andrey G., Komarova, Ekaterina S., Syroegin, Egor A., Shiriaev, Dmitrii I., Paleskava, Alena, Kartsev, Victor G., Bogdanov, Alexey A., Konevega, Andrey L., Dontsova, Olga A., Sergiev, Petr V., Osterman, Ilya A., Polikanov, Yury S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
Assuntos:
Chemistry; Biosynthesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535518/
https://ncbi.nlm.nih.gov/pubmed/30936109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02266-18
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