Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides

Although macrolides are known as excellent antibacterials, their medical use has been significantly limited due to the spread of bacterial drug resistance. Therefore, it is necessary to develop new potent macrolides to combat the emergence of drug-resistant pathogens. One of the key steps in rationa...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Khabibullina, Nelli F., Tereshchenkov, Andrey G., Komarova, Ekaterina S., Syroegin, Egor A., Shiriaev, Dmitrii I., Paleskava, Alena, Kartsev, Victor G., Bogdanov, Alexey A., Konevega, Andrey L., Dontsova, Olga A., Sergiev, Petr V., Osterman, Ilya A., Polikanov, Yury S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Chemistry; Biosynthesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535518/
https://ncbi.nlm.nih.gov/pubmed/30936109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02266-18
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