Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state

The emergence of multi-drug resistant bacteria is limiting the effectiveness of commonly used antibiotics, which spurs a renewed interest in revisiting older and poorly studied drugs. Streptogramins A is a class of protein synthesis inhibitors that target the peptidyl transferase center (PTC) on the...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Osterman, Ilya A., Khabibullina, Nelli F., Komarova, Ekaterina S., Kasatsky, Pavel, Kartsev, Victor G., Bogdanov, Alexey A., Dontsova, Olga A., Konevega, Andrey L., Sergiev, Petr V., Polikanov, Yury S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499580/
https://ncbi.nlm.nih.gov/pubmed/28505372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx413
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