Engineering the acyltransferase domain of epothilone polyketide synthase to alter the substrate specificity

BACKGROUND: Polyketide synthases (PKSs) include ketone synthase (KS), acyltransferase (AT) and acyl carrier protein (ACP) domains to catalyse the elongation of polyketide chains. Some PKSs also contain ketoreductase (KR), dehydratase (DH) and enoylreductase (ER) domains as modification domains. Inse...

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Dettagli Bibliografici
Pubblicato in:Microb Cell Fact
Autori principali: Wang, Huimin, Liang, Junheng, Yue, Qianwen, Li, Long, Shi, Yan, Chen, Guosong, Li, Yue-zhong, Bian, Xiaoying, Zhang, Youming, Zhao, Guoping, Ding, Xiaoming
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058987/
https://ncbi.nlm.nih.gov/pubmed/33882930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-021-01578-3
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