Engineering the acyltransferase domain of epothilone polyketide synthase to alter the substrate specificity

BACKGROUND: Polyketide synthases (PKSs) include ketone synthase (KS), acyltransferase (AT) and acyl carrier protein (ACP) domains to catalyse the elongation of polyketide chains. Some PKSs also contain ketoreductase (KR), dehydratase (DH) and enoylreductase (ER) domains as modification domains. Inse...

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Publicado en:Microb Cell Fact
Main Authors: Wang, Huimin, Liang, Junheng, Yue, Qianwen, Li, Long, Shi, Yan, Chen, Guosong, Li, Yue-zhong, Bian, Xiaoying, Zhang, Youming, Zhao, Guoping, Ding, Xiaoming
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2021
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058987/
https://ncbi.nlm.nih.gov/pubmed/33882930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-021-01578-3
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