Engineering the acyltransferase domain of epothilone polyketide synthase to alter the substrate specificity

BACKGROUND: Polyketide synthases (PKSs) include ketone synthase (KS), acyltransferase (AT) and acyl carrier protein (ACP) domains to catalyse the elongation of polyketide chains. Some PKSs also contain ketoreductase (KR), dehydratase (DH) and enoylreductase (ER) domains as modification domains. Inse...

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Bibliografske podrobnosti
izdano v:Microb Cell Fact
Main Authors: Wang, Huimin, Liang, Junheng, Yue, Qianwen, Li, Long, Shi, Yan, Chen, Guosong, Li, Yue-zhong, Bian, Xiaoying, Zhang, Youming, Zhao, Guoping, Ding, Xiaoming
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058987/
https://ncbi.nlm.nih.gov/pubmed/33882930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-021-01578-3
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