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Engineering the acyltransferase domain of epothilone polyketide synthase to alter the substrate specificity
BACKGROUND: Polyketide synthases (PKSs) include ketone synthase (KS), acyltransferase (AT) and acyl carrier protein (ACP) domains to catalyse the elongation of polyketide chains. Some PKSs also contain ketoreductase (KR), dehydratase (DH) and enoylreductase (ER) domains as modification domains. Inse...
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| Udgivet i: | Microb Cell Fact |
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| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8058987/ https://ncbi.nlm.nih.gov/pubmed/33882930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-021-01578-3 |
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