Engineering the acyltransferase domain of epothilone polyketide synthase to alter the substrate specificity

BACKGROUND: Polyketide synthases (PKSs) include ketone synthase (KS), acyltransferase (AT) and acyl carrier protein (ACP) domains to catalyse the elongation of polyketide chains. Some PKSs also contain ketoreductase (KR), dehydratase (DH) and enoylreductase (ER) domains as modification domains. Inse...

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Vydáno v:Microb Cell Fact
Hlavní autoři: Wang, Huimin, Liang, Junheng, Yue, Qianwen, Li, Long, Shi, Yan, Chen, Guosong, Li, Yue-zhong, Bian, Xiaoying, Zhang, Youming, Zhao, Guoping, Ding, Xiaoming
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058987/
https://ncbi.nlm.nih.gov/pubmed/33882930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-021-01578-3
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