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1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases

1,2-Naphthoquinone, a secondary metabolite of naphthalene, is an environmental pollutant found in diesel exhaust particles that displays cytotoxic and genotoxic properties. Because many quinones have been shown to act as topoisomerase II poisons, the effects of this compound on DNA cleavage mediated...

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Bibliografiske detaljer
Udgivet i:Chem Res Toxicol
Main Authors: Collins, Jessica A., Osheroff, Neil
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058326/
https://ncbi.nlm.nih.gov/pubmed/33760604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.0c00492
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