REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model

Alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson's patients. Working across human and mouse models, we investigated mechanisms by which the accumulation of soluble α-synuclein oligomers leads to neurodegeneration. Biochemical anal...

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Detaylı Bibliyografya
Yayımlandı:J Neurosci
Asıl Yazarlar: Ryan, Brent J., Bengoa-Vergniory, Nora, Williamson, Matthew, Kirkiz, Ecem, Roberts, Rosalind, Corda, Gabriele, Sloan, Maximilian, Saqlain, Saba, Cherubini, Marta, Poppinga, Josse, Bogtofte, Helle, Cioroch, Milena, Hester, Svenja, Wade-Martins, Richard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2021
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055072/
https://ncbi.nlm.nih.gov/pubmed/33563726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1478-20.2021
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