REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model

Alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson's patients. Working across human and mouse models, we investigated mechanisms by which the accumulation of soluble α-synuclein oligomers leads to neurodegeneration. Biochemical anal...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Ryan, Brent J., Bengoa-Vergniory, Nora, Williamson, Matthew, Kirkiz, Ecem, Roberts, Rosalind, Corda, Gabriele, Sloan, Maximilian, Saqlain, Saba, Cherubini, Marta, Poppinga, Josse, Bogtofte, Helle, Cioroch, Milena, Hester, Svenja, Wade-Martins, Richard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2021
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055072/
https://ncbi.nlm.nih.gov/pubmed/33563726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1478-20.2021
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