REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model

Alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson's patients. Working across human and mouse models, we investigated mechanisms by which the accumulation of soluble α-synuclein oligomers leads to neurodegeneration. Biochemical anal...

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書誌詳細
出版年:J Neurosci
主要な著者: Ryan, Brent J., Bengoa-Vergniory, Nora, Williamson, Matthew, Kirkiz, Ecem, Roberts, Rosalind, Corda, Gabriele, Sloan, Maximilian, Saqlain, Saba, Cherubini, Marta, Poppinga, Josse, Bogtofte, Helle, Cioroch, Milena, Hester, Svenja, Wade-Martins, Richard
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2021
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055072/
https://ncbi.nlm.nih.gov/pubmed/33563726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1478-20.2021
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