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Chemoproteomics-Enabled Discovery of Covalent RNF114-Based Degraders that Mimic Natural Product Function
The translation of functionally active natural products into fully synthetic small molecule mimetics has remained an important process in medicinal chemistry. We recently discovered that the terpene natural product nimbolide can be utilized as a covalent recruiter of the E3 ubiquitin ligase RNF114 f...
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| 出版年: | Cell Chem Biol |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8052289/ https://ncbi.nlm.nih.gov/pubmed/33513350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2021.01.005 |
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