Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine Within MYC

MYC is a major oncogenic transcriptional driver of most human cancers that has remained intractable to direct targeting because much of MYC is intrinsically disordered. Here, we have performed a cysteine-reactive covalent ligand screen to identify compounds that could disrupt the binding of MYC to i...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell Chem Biol
Asıl Yazarlar: Boike, Lydia, Cioffi, Alexander G., Majewski, Felix C., Co, Jennifer, Henning, Nathaniel J., Jones, Michael D., Liu, Gang, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854864/
https://ncbi.nlm.nih.gov/pubmed/32966806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.09.001
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller