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Covalent Ligand Discovery Against Druggable Hotspots Targeted by Anti-Cancer Natural Products

Many natural products that show therapeutic activities are oftentimes difficult to synthesize or isolate and have unknown targets, hindering their development as drugs. Identifying druggable hotspots targeted by covalently-acting anti-cancer natural products can enable pharmacological interrogation...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Chem Biol
Egile Nagusiak: Grossman, Elizabeth A., Ward, Carl C., Spradlin, Jessica N., Bateman, Leslie A., Huffman, Tucker R., Miyamoto, David K., Kleinman, Jordan I., Nomura, Daniel K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693770/
https://ncbi.nlm.nih.gov/pubmed/28919038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.08.013
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