Загрузка...
Chemoproteomics-Enabled Covalent Ligand Screen Reveals a Cysteine Hotspot in Reticulon 4 that Impairs ER Morphology and Cancer Pathogenicity
Chemical genetics has arisen as a powerful approach for identifying novel anti-cancer agents. However, a major bottleneck of this approach is identifying the targets of lead compounds that arise from screens. Here, we coupled the synthesis and screening of fragment-based cysteine-reactive covalent l...
Сохранить в:
| Опубликовано в: : | Chem Commun (Camb) |
|---|---|
| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5491356/ https://ncbi.nlm.nih.gov/pubmed/28352901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc01480e |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|