Chemoproteomics-Enabled Covalent Ligand Screen Reveals a Cysteine Hotspot in Reticulon 4 that Impairs ER Morphology and Cancer Pathogenicity

Chemical genetics has arisen as a powerful approach for identifying novel anti-cancer agents. However, a major bottleneck of this approach is identifying the targets of lead compounds that arise from screens. Here, we coupled the synthesis and screening of fragment-based cysteine-reactive covalent l...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Chem Commun (Camb)
Autori principali: Bateman, L.A., Nguyen, T.B., Roberts, A.M., Miyamoto, D.K., Ku, W-M., Huffman, T.R., Petri, Y., Heslin, M.J., Contreras, C.M., Skibola, C.F., Olzmann, J.A., Nomura, D.K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491356/
https://ncbi.nlm.nih.gov/pubmed/28352901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc01480e
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi