Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine Within MYC

MYC is a major oncogenic transcriptional driver of most human cancers that has remained intractable to direct targeting because much of MYC is intrinsically disordered. Here, we have performed a cysteine-reactive covalent ligand screen to identify compounds that could disrupt the binding of MYC to i...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Boike, Lydia, Cioffi, Alexander G., Majewski, Felix C., Co, Jennifer, Henning, Nathaniel J., Jones, Michael D., Liu, Gang, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854864/
https://ncbi.nlm.nih.gov/pubmed/32966806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.09.001
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