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Bardoxolone conjugation enables targeted protein degradation of BRD4
Targeted protein degradation (TPD) has emerged as a powerful tool in drug discovery for the perturbation of protein levels using heterobifunctional small molecules. E3 ligase recruiters remain central to this process yet relatively few have been identified relative to the ~ 600 predicted human E3 li...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7511954/ https://ncbi.nlm.nih.gov/pubmed/32968148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72491-9 |
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