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Bardoxolone conjugation enables targeted protein degradation of BRD4
Targeted protein degradation (TPD) has emerged as a powerful tool in drug discovery for the perturbation of protein levels using heterobifunctional small molecules. E3 ligase recruiters remain central to this process yet relatively few have been identified relative to the ~ 600 predicted human E3 li...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7511954/ https://ncbi.nlm.nih.gov/pubmed/32968148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72491-9 |
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