Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation

Neuroinflammation characterizes multiple neurologic diseases, including primary inflammatory conditions such as multiple sclerosis and classical neurodegenerative diseases. Aberrant activation of the innate immune system contributes to disease progression, but drugs modulating innate immunity, parti...

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Bibliografiset tiedot
Julkaisussa:Cell Chem Biol
Päätekijät: Abramson, Efrat, Hardman, Clayton, Shimizu, Akira J., Hwang, Soonmyung, Hester, Lynda D., Snyder, Solomon H., Wender, Paul A., Kim, Paul M., Kornberg, Michael D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052272/
https://ncbi.nlm.nih.gov/pubmed/33472023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.12.015
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