Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation

Neuroinflammation characterizes multiple neurologic diseases, including primary inflammatory conditions such as multiple sclerosis and classical neurodegenerative diseases. Aberrant activation of the innate immune system contributes to disease progression, but drugs modulating innate immunity, parti...

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Gepubliceerd in:Cell Chem Biol
Hoofdauteurs: Abramson, Efrat, Hardman, Clayton, Shimizu, Akira J., Hwang, Soonmyung, Hester, Lynda D., Snyder, Solomon H., Wender, Paul A., Kim, Paul M., Kornberg, Michael D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052272/
https://ncbi.nlm.nih.gov/pubmed/33472023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.12.015
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