Retinal degeneration-3 protein promotes photoreceptor survival by suppressing activation of guanylyl cyclase rather than accelerating GMP recycling

Retinal degeneration-3 protein (RD3) deficiency causes photoreceptor dysfunction and rapid degeneration in the rd3 mouse strain and in human Leber’s congenital amaurosis, a congenital retinal dystrophy that results in early vision loss. However, the mechanisms responsible for photoreceptor death rem...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Dizhoor, Alexander M., Olshevskaya, Elena V., Peshenko, Igor V.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047982/
https://ncbi.nlm.nih.gov/pubmed/33539922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100362
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