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Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness

Deficiency of RD3 (retinal degeneration 3) protein causes recessive blindness and photoreceptor degeneration in humans and in the rd3 mouse strain, but the disease mechanism is unclear. Here, we present evidence that RD3 protects photoreceptors from degeneration by competing with guanylyl cyclase-ac...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Dizhoor, Alexander M., Olshevskaya, Elena V., Peshenko, Igor V.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746453/
https://ncbi.nlm.nih.gov/pubmed/31346032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009948
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