Retinal Guanylyl Cyclase Isozyme 1 Is the Preferential In Vivo Target for Constitutively Active GCAP1 Mutants Causing Congenital Degeneration of Photoreceptors

Two calcium-sensitive guanylyl cyclase activating proteins (GCAP1 and GCAP2) activate cGMP synthesis in photoreceptor by retinal membrane guanylyl cyclase isozymes (RetGC1 and RetGC2) to expedite recovery, but calcium-insensitive constitutively active GCAP1 mutants cause photoreceptor degeneration i...

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Hlavní autoři: Olshevskaya, Elena V., Peshenko, Igor V., Savchenko, Andrey B., Dizhoor, Alexander M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368705/
https://ncbi.nlm.nih.gov/pubmed/22623665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0976-12.2012
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