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Mg(2+)/Ca(2+) cation binding cycle of guanylyl cyclase activating proteins (GCAPs): role in regulation of photoreceptor guanylyl cyclase

Photon absorption by photoreceptors activates hydrolysis of cGMP, which shuts down cGMP-gated channels and decreases free Ca(2+) concentrations in outer segment. Suppression of Ca(2+) influx through the cGMP channel by light activates retinal guanylyl cyclase through guanylyl cyclase activating prot...

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Detalhes bibliográficos
Main Authors: Dizhoor, Alexander M., Olshevskaya, Elena V., Peshenko, Igor V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824334/
https://ncbi.nlm.nih.gov/pubmed/19953307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-009-0328-6
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