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The R838S Mutation in Retinal Guanylyl Cyclase 1 (RetGC1) Alters Calcium Sensitivity of cGMP Synthesis in the Retina and Causes Blindness in Transgenic Mice

Substitutions of Arg(838) in the dimerization domain of a human retinal membrane guanylyl cyclase 1 (RetGC1) linked to autosomal dominant cone-rod degeneration type 6 (CORD6) change RetGC1 regulation in vitro by Ca(2+). In addition, we find that R838S substitution makes RetGC1 less sensitive to inhi...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Dizhoor, Alexander M., Olshevskaya, Elena V., Peshenko, Igor V.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114404/
https://ncbi.nlm.nih.gov/pubmed/27703005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.755553
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