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The R838S Mutation in Retinal Guanylyl Cyclase 1 (RetGC1) Alters Calcium Sensitivity of cGMP Synthesis in the Retina and Causes Blindness in Transgenic Mice
Substitutions of Arg(838) in the dimerization domain of a human retinal membrane guanylyl cyclase 1 (RetGC1) linked to autosomal dominant cone-rod degeneration type 6 (CORD6) change RetGC1 regulation in vitro by Ca(2+). In addition, we find that R838S substitution makes RetGC1 less sensitive to inhi...
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| Publicat a: | J Biol Chem |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5114404/ https://ncbi.nlm.nih.gov/pubmed/27703005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.755553 |
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