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Activation of Retinal Guanylyl Cyclase RetGC1 by GCAP1: Stoichiometry of Binding and the Effect of New LCA-Related Mutations

Retinal membrane guanylyl cyclase (retGC) and Ca(2+)/Mg(2+) -sensor proteins, GCAPs(1), control the recovery of the photoresponse in vertebrate photoreceptors, through their molecular interactions that remain rather poorly understood and controversial. Here we have determined the main retGC isozyme...

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Detalhes bibliográficos
Main Authors: Peshenko, Igor V., Olshevskaya, Elena V., Yao, Suxia, Ezzeldin, Hany H., Pittler, Steven J., Dizhoor, Alexander M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827208/
https://ncbi.nlm.nih.gov/pubmed/20050595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901495y
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