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Mitochondrial translation deficiency impairs NAD(+)‐mediated lysosomal acidification

Mitochondrial translation dysfunction is associated with neurodegenerative and cardiovascular diseases. Cells eliminate defective mitochondria by the lysosomal machinery via autophagy. The relationship between mitochondrial translation and lysosomal function is unknown. In this study, mitochondrial...

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Bibliographic Details
Published in:EMBO J
Main Authors: Yagi, Mikako, Toshima, Takahiro, Amamoto, Rie, Do, Yura, Hirai, Haruka, Setoyama, Daiki, Kang, Dongchon, Uchiumi, Takeshi
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047443/
https://ncbi.nlm.nih.gov/pubmed/33528041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020105268
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