Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction

Some mutations of the DHODH (dihydro-orotate dehydrogenase) gene lead to postaxial acrofacial dysostosis or Miller syndrome. Only DHODH is localized at mitochondria among enzymes of the de novo pyrimidine biosynthesis pathway. Since the pyrimidine biosynthesis pathway is coupled to the mitochondrial...

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Détails bibliographiques
Auteurs principaux: Fang, JingXian, Uchiumi, Takeshi, Yagi, Mikako, Matsumoto, Shinya, Amamoto, Rie, Takazaki, Shinya, Yamaza, Haruyoshi, Nonaka, Kazuaki, Kang, Dongchon
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2013
Sujets:
Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564035/
https://ncbi.nlm.nih.gov/pubmed/23216091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120097
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