Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction

Some mutations of the DHODH (dihydro-orotate dehydrogenase) gene lead to postaxial acrofacial dysostosis or Miller syndrome. Only DHODH is localized at mitochondria among enzymes of the de novo pyrimidine biosynthesis pathway. Since the pyrimidine biosynthesis pathway is coupled to the mitochondrial...

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Detalhes bibliográficos
Main Authors: Fang, JingXian, Uchiumi, Takeshi, Yagi, Mikako, Matsumoto, Shinya, Amamoto, Rie, Takazaki, Shinya, Yamaza, Haruyoshi, Nonaka, Kazuaki, Kang, Dongchon
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2013
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564035/
https://ncbi.nlm.nih.gov/pubmed/23216091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120097
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