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Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration

Mitochondrial dysfunction is a critical step in the pathogenesis of many neurodegenerative diseases. The p32/ C1qbp gene functions as an essential RNA and protein chaperone in mitochondrial translation, and is indispensable for embryonic development. However, little is known about the consequences o...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Yagi, Mikako, Uchiumi, Takeshi, Sagata, Noriaki, Setoyama, Daiki, Amamoto, Rie, Matsushima, Yuichi, Kang, Dongchon
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680297/
https://ncbi.nlm.nih.gov/pubmed/29123152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15414-5
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