Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response

Mitochondrial–nuclear communication, known as retrograde signaling, is important for regulating nuclear gene expression in response to mitochondrial dysfunction. Previously, we have found that p32/C1qbp-deficient mice, which have a mitochondrial translation defect, show endoplasmic reticulum (ER) st...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Sasaki, Katsuhiko, Uchiumi, Takeshi, Toshima, Takahiro, Yagi, Mikako, Do, Yura, Hirai, Haruka, Igami, Ko, Gotoh, Kazuhito, Kang, Dongchon
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2020
Assuntos:
Molecular Bases of Health & Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685009/
https://ncbi.nlm.nih.gov/pubmed/33165592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20201289
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