Cardioprotection by the mitochondrial unfolded protein response requires ATF5

The mitochondrial unfolded protein response (UPR(mt)) is a cytoprotective signaling pathway triggered by mitochondrial dysfunction. UPR(mt) activation upregulates chaperones, proteases, antioxidants, and glycolysis at the gene level to restore proteostasis and cell energetics. Activating transcripti...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Wang, Yves T., Lim, Yunki, McCall, Matthew N., Huang, Kai-Ting, Haynes, Cole M., Nehrke, Keith, Brookes, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Rapid Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732477/
https://ncbi.nlm.nih.gov/pubmed/31274354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00244.2019
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