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Cardioprotection by the mitochondrial unfolded protein response requires ATF5
The mitochondrial unfolded protein response (UPR(mt)) is a cytoprotective signaling pathway triggered by mitochondrial dysfunction. UPR(mt) activation upregulates chaperones, proteases, antioxidants, and glycolysis at the gene level to restore proteostasis and cell energetics. Activating transcripti...
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| Vydáno v: | Am J Physiol Heart Circ Physiol |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Physiological Society
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6732477/ https://ncbi.nlm.nih.gov/pubmed/31274354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00244.2019 |
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