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Mechanistic Investigation of 1,2-Diol Dehydration of Paromamine Catalyzed by the Radical S-adenosyl-l-methionine Enzyme AprD4

AprD4 is a radical S-adenosyl-l-methionine (SAM) enzyme catalyzing C3′-deoxygenation of paromamine to form 4′-oxo-lividamine. It is the only 1,2-diol dehydratase in the radical SAM enzyme superfamily that has been identified and characterized in vitro. The AprD4 catalyzed 1,2-diol dehydration is a k...

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Bibliografiset tiedot
Julkaisussa:J Am Chem Soc
Päätekijät: Yeh, Yu-Cheng, Kim, Hak Joong, Liu, Hung-wen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045149/
https://ncbi.nlm.nih.gov/pubmed/33784078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c00076
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