Mechanistic Investigations of PoyD, a Radical S-Adenosyl-l-methionine Enzyme Catalyzing Iterative and Directional Epimerizations in Polytheonamide A Biosynthesis

[Image: see text] Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing family of bioactive peptides. Among RiPPs, the bacterial toxin polytheonamide A is characterized by a unique set of post-translational modifications catalyzed by novel radical S-adenosyl-l-meth...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Parent, Aubérie, Benjdia, Alhosna, Guillot, Alain, Kubiak, Xavier, Balty, Clémence, Lefranc, Benjamin, Leprince, Jérôme, Berteau, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824343/
https://ncbi.nlm.nih.gov/pubmed/29253341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08402
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