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Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes

Despite its major importance in human health, the metabolic potential of the human gut microbiota is still poorly understood. We have recently shown that biosynthesis of Ruminococcin C (RumC), a novel ribosomally synthesized and posttranslationally modified peptide (RiPP) produced by the commensal b...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Balty, Clémence, Guillot, Alain, Fradale, Laura, Brewee, Clémence, Lefranc, Benjamin, Herrero, Christian, Sandström, Corine, Leprince, Jérôme, Berteau, Olivier, Benjdia, Alhosna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188230/
https://ncbi.nlm.nih.gov/pubmed/32972973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015371
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