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Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes

Despite its major importance in human health, the metabolic potential of the human gut microbiota is still poorly understood. We have recently shown that biosynthesis of Ruminococcin C (RumC), a novel ribosomally synthesized and posttranslationally modified peptide (RiPP) produced by the commensal b...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Balty, Clémence, Guillot, Alain, Fradale, Laura, Brewee, Clémence, Lefranc, Benjamin, Herrero, Christian, Sandström, Corine, Leprince, Jérôme, Berteau, Olivier, Benjdia, Alhosna
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188230/
https://ncbi.nlm.nih.gov/pubmed/32972973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015371
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