Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes

Despite its major importance in human health, the metabolic potential of the human gut microbiota is still poorly understood. We have recently shown that biosynthesis of Ruminococcin C (RumC), a novel ribosomally synthesized and posttranslationally modified peptide (RiPP) produced by the commensal b...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Balty, Clémence, Guillot, Alain, Fradale, Laura, Brewee, Clémence, Lefranc, Benjamin, Herrero, Christian, Sandström, Corine, Leprince, Jérôme, Berteau, Olivier, Benjdia, Alhosna
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188230/
https://ncbi.nlm.nih.gov/pubmed/32972973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015371
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