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C3′-Deoxygenation of paromamine catalyzed by a radical SAM enzyme: Characterization of AprD4 and its reductase partner AprD3()
C3′-deoxygenation of aminoglycosides results in their decreased susceptibility to phosphorylation thereby increasing their efficacy as antibiotics. However, the biosynthetic mechanism of C3′-deoxygenation is unknown. To address this question, aprD4 and aprD3 genes from the apramycin gene cluster in...
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| Publié dans: | Angew Chem Int Ed Engl |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4943880/ https://ncbi.nlm.nih.gov/pubmed/26879038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201510635 |
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