The GenK-catalyzed C-6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-dependent Radical SAM Enzyme

The existence of cobalamin (Cbl)-dependent enzymes that are members of the radical S-adenosyl-L-methionine (SAM) superfamily was previously predicted based on bioinformatic analysis. A number of these are Cbl-dependent methyltransferases but the details surrounding their reaction mechanisms have rem...

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Hlavní autoři: Kim, Hak Joong, McCarty, Reid M., Ogasawara, Yasushi, Liu, Yung-nan, Mansoorabadi, Steven O., LeVieux, Jake, Liu, Hung-wen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796153/
https://ncbi.nlm.nih.gov/pubmed/23679096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja312641f
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