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Characterization and Mechanistic Studies of DesII: A Radical S-Adenosyl-L-methionine Enzyme Involved in the Biosynthesis of TDP-D-Desosamine
D-Desosamine (1) is a 3-(N,N-dimethylamino)-3,4,6-trideoxyhexose found in a number of macrolide antibiotics including methymycin (2), neomethymycin (3), pikromycin (4), and narbomycin (5) produced by Streptomyces venezuelae. It plays an essential role in conferring biological activities to its paren...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2780582/ https://ncbi.nlm.nih.gov/pubmed/19746907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja903354k |
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