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Mechanistic Investigation of the Radical S-Adenosyl-l-methionine (SAM) Enzyme DesII Using Fluorinated Analogs
DesII is a radical S-adenosyl-l-methionine (SAM) enzyme that can act as a deaminase or a dehydrogenase depending on the nature of its TDP-sugar substrate. Previous work has implicated a substrate-derived, C3-centered α-hydroxyalkyl radical as a key intermediate during catalysis. Although deprotonati...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4862307/ https://ncbi.nlm.nih.gov/pubmed/25826575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b02545 |
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