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Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

Tau and Aβ assemblies of Alzheimer’s disease (AD) can be visualized in living subjects using positron emission tomography (PET). Tau assemblies comprise paired helical and straight filaments (PHFs and SFs). APN-1607 (PM-PBB3) is a recently described PET ligand for AD and other tau proteinopathies. S...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Shi, Yang, Murzin, Alexey G., Falcon, Benjamin, Epstein, Alexander, Machin, Jonathan, Tempest, Paul, Newell, Kathy L., Vidal, Ruben, Garringer, Holly J., Sahara, Naruhiko, Higuchi, Makoto, Ghetti, Bernardino, Jang, Ming-Kuei, Scheres, Sjors H. W., Goedert, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043864/
https://ncbi.nlm.nih.gov/pubmed/33723967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-021-02294-3
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