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Cryo-EM structures of Tau filaments from Alzheimer’s disease brain
Alzheimer’s disease (AD) is the most common neurodegenerative disease, and there are no mechanism-based therapies. AD is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in cerebral cortex. Neurofibrillary lesions are made of paired helical and straight Tau filaments...
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| Veröffentlicht in: | Nature |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5552202/ https://ncbi.nlm.nih.gov/pubmed/28678775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23002 |
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