Cryo-EM structures of Tau filaments from Alzheimer’s disease brain

Alzheimer’s disease (AD) is the most common neurodegenerative disease, and there are no mechanism-based therapies. AD is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in cerebral cortex. Neurofibrillary lesions are made of paired helical and straight Tau filaments...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nature
Päätekijät: Fitzpatrick, Anthony W.P., Falcon, Benjamin, He, Shaoda, Murzin, Alexey G., Murshudov, Garib, Garringer, Holly J., Crowther, R. Anthony, Ghetti, Bernardino, Goedert, Michel, Scheres, Sjors H.W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552202/
https://ncbi.nlm.nih.gov/pubmed/28678775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23002
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