Cryo-EM structures of Tau filaments from Alzheimer’s disease brain

Alzheimer’s disease (AD) is the most common neurodegenerative disease, and there are no mechanism-based therapies. AD is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in cerebral cortex. Neurofibrillary lesions are made of paired helical and straight Tau filaments...

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Udgivet i:Nature
Main Authors: Fitzpatrick, Anthony W.P., Falcon, Benjamin, He, Shaoda, Murzin, Alexey G., Murshudov, Garib, Garringer, Holly J., Crowther, R. Anthony, Ghetti, Bernardino, Goedert, Michel, Scheres, Sjors H.W.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552202/
https://ncbi.nlm.nih.gov/pubmed/28678775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23002
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